Hi DabOnThem. If its just renaming, i am pretty sure that can be done. My comment is based on what ive seen done by other modders with the UI, not on 1st-hand knowledge of my own.
Lets hope one of the UI modders drops by and sees/answers ur question.
Do the health/mana orbs even have names? I assume you mean the tooltip when you mouse over them. If that's the case, you'll have to dive in and scour Guts for the UI tooltips. It should be possible to find the particular prompt unless it's hard-coded.