Glad to see someone else join in on the discussion (It felt like talking to a mirror
For me a speed run is about high damage. You want to be able to kill everything in 1 shot. Champions will take 2+ shots but killing them gives you the biggest boost in exp/fame.
Playing on easy only requires enough Defense to wear armor (which should boost damage/crits). The penalty for dying isn't much.
I haven't tried bypassing all monsters and only killing the bosses. Unless you have a super gear to wear when you are level 5-10 it may take a long time to do it (especially Ordrak).
One suggestion would be to kill only champion monsters so at least you will gain some levels to boost skills.
Essentially the skills will be 1 damage skill, 2 passives ( *Weapon Expertise, Critical Strike) and a fourth (Dual Wielding, Armor, a Titan skill, etc)
Giving a toon lots of health/mana potions to start with is the way to go. Gotta spend the gold on something.
Right now I think Explosive Shot is the best killing skill because of the weapon bonus and damage radius. Ricochet might be on par because it passes through enemies and gives a higher bonus.
It is a pain to fight the 2 bosses before Ordrak because they can repel projectiles. Haven't tried the other two skill tabs.
My next 2 Alchs will use Ember Lightning and Ember Lance just to see if they work better than Ember Bolt. The Lore tab is useless for speed. Might pick your 4th skill from Battle tab (infuse/armor).
Charon's destroyer used Stampede which I will try with my next Destroyer. I haven't used any of the Titan skills before. I am going to have to experiment with the destroyer skills.